Centella Asiatica Extract (Asiaticoside)

What is Centella Asiatica Extract?

Centella Asiatica Extract, enriched with Asiaticoside, is a high-value botanical ingredient widely recognized for its skin-supportive properties. Derived from the leaves and stems of Centella asiatica (L.) Urban, a member of the Apiaceae (Umbelliferae) family, this extract has been traditionally used in Asian medicine for skin rejuvenation, wound care, and topical applications.

As global research expands, Centella Asiatica Extract has become a sought-after raw material in cosmetic, pharmaceutical, and nutraceutical industries, particularly for formulations targeting skin barrier integrity, wound management, and dermal health.

Botanical Origin and Traditional Applications

Centella asiatica, commonly known as Gotu Kola, has been employed for centuries in Ayurvedic, Chinese, and Southeast Asian medicine. The leaves and stems contain triterpenoid glycosides, primarily Asiaticoside and Madecassoside, which have been linked to skin-supportive activity. Traditional uses include:

· Topical application for minor skin lesions and abrasions

· Support of skin hydration and elasticity

· Herbal adjunct for skin barrier maintenance

Research suggests that these traditional applications align with the pharmacological potential of Asiaticoside, particularly in dermal repair and antioxidant defense (PubMed: 18311245).

Extraction Technology and Quality Assurance

Shaanxi Bolin Biotechnology Co., Ltd. utilizes advanced solvent extraction and chromatographic purification technologies to obtain Centella Asiatica Extract powder with consistent Asiaticoside content. Key quality control measures include:

· High-Performance Liquid Chromatography (HPLC) for Asiaticoside quantification

· Microbial limit testing to comply with ISO 22716 Good Manufacturing Practices (GMP)

· Batch-to-batch consistency with strict purity and moisture content specifications

Available purities range from 10% to 99% Asiaticoside, ensuring flexibility for diverse industrial applications.

Core Active Ingredient: Asiaticoside

Chemical Characteristics

Asiaticoside (CAS No. 16830-15-2) is a pentacyclic triterpenoid saponin with the molecular formula C48H78O19 and a molecular weight of 959.12 g/mol. It appears as a white powder with a density of 1.44±0.1 g/cm³. Its structural configuration supports:

· Interaction with collagen synthesis pathways

· Modulation of inflammatory cytokines

· Antioxidant defense enhancement

Quality Specifications

Shaanxi Bolin Biotechnology Co., Ltd. provides Asiaticoside cosmetic raw material in multiple grades:

These specifications meet FDA dietary supplement guidelines, EU Cosmetics Regulation (EC) No 1223/2009, and ISO standards, providing professional buyers with confidence for formulation purposes.

Scientifically Supported Benefits

Anti-Inflammatory Activity

Clinical studies indicate that Asiaticoside may support skin health by reducing pro-inflammatory markers. In vitro experiments demonstrate the suppression of NF-κB pathway activation, suggesting potential use in formulations for sensitive or irritated skin (PubMed: 22158602).

Antioxidant Properties

Centella Asiatica Extract contains triterpenoids and flavonoids that help neutralize free radicals, potentially mitigating oxidative stress in dermal tissues. Research shows enhanced superoxide dismutase (SOD) activity in fibroblast cultures treated with Asiaticoside (PubMed: 27862785).

Skin Barrier Support

Evidence suggests that Centella Asiatica Glycoside may help maintain stratum corneum integrity, improving skin hydration and resilience. Topical formulations have been investigated for supporting the epidermal barrier in dry and aging skin (CosIng Database).

Wound Healing Potential

Asiaticoside has been studied for its role in collagen synthesis modulation and angiogenesis promotion, indicating potential to support wound closure and dermal tissue repair (PubMed: 19335634).

Scar Appearance Improvement

Clinical observations suggest that Centella Asiatica Extract scar treatment formulations may improve the appearance of hypertrophic scars and minor burn scars by promoting organized collagen deposition (PubMed: 29599693).

Industrial Applications

Cosmetic Industry

· Formulations for anti-aging creams, serums, and masks

· Sensitive skin care products targeting redness or irritation

· Ingredients in sun protection and post-sun repair formulations

Pharmaceutical Industry

· Topical gels for minor wounds and post-procedural skin care

· Supportive adjunct in dermatology clinical formulations

Personal Care Products

· Soothing body lotions and balms

· Herbal-infused shampoos for scalp health

· Hand and foot creams targeting skin integrity

Synergistic Formulation Opportunities

Centella Asiatica Extract + Panthenol

Combining Asiaticoside with Panthenol may enhance skin hydration and epithelial repair, supporting barrier restoration.

Centella Asiatica Extract + Hyaluronic Acid

The moisturizing capacity of Hyaluronic Acid complements the dermal repair activity of Centella Asiatica Extract, suitable for serums and moisturizers.

Centella Asiatica Extract + Shea Butter

Shea Butter provides emollient properties, enhancing skin barrier function while Centella Asiatica Extract supports microvascular and collagen health.

Manufacturing Advantages

Shaanxi Bolin Biotechnology Production Strength

· 20+ years of botanical extract manufacturing experience

· ISO 9001 and GMP-certified facilities

· Advanced chromatography and extraction lines ensuring consistent Asiaticoside content

OEM/ODM Capabilities

· Custom formulations and private label support

· Flexible batch sizes for R&D, pilot, and full-scale production

· Technical support for regulatory compliance and product stability

Packaging and Storage

· Aluminum foil bags, PE inner bags, or drum packaging

· Storage in cool, dry, and ventilated areas

· Recommended shelf life: 24 months in original sealed containers

Certifications and Compliance

· ISO 9001:2015 Quality Management

· GMP Certification for dietary supplements and cosmetic ingredients

· Halal and Kosher certificates available upon request

· Fully compliant with FDA, EU Cosmetic Regulation (EC) No 1223/2009, and FTC advertising guidelines

Frequently Asked Questions

1.         What is the primary active component of Centella Asiatica Extract?

o  Asiaticoside, a triterpenoid saponin, is the main bioactive compound.

2.         Can Centella Asiatica Extract support wound healing?

o  Research suggests it may enhance collagen synthesis and angiogenesis, supporting wound repair.

3.         What concentrations of Asiaticoside are available?

o  From 10% to 99% purity, depending on formulation needs.

4.         Is Centella Asiatica Extract safe for cosmetic use?

o  Yes, it complies with EU Cosmetic Regulation 1223/2009 and FDA guidelines.

5.         Can this extract be used in sensitive skin formulations?

o  Clinical studies indicate potential anti-inflammatory and barrier-supportive properties.

6.         How should Centella Asiatica Extract be stored?

o  In sealed containers, away from light, moisture, and heat.

7.         What are common formulation combinations?

o  With Panthenol, Hyaluronic Acid, or Shea Butter for synergistic effects.

8.         Does the extract contain Madecassoside?

o  Yes, it naturally contains Madecassoside, Asiatic Acid, and Madecassic Acid.

9.         Can Shaanxi Bolin Biotechnology provide OEM/ODM services?

o  Yes, they offer full support for custom formulations and private labeling.

10.      How can I request a sample?

o  Contact sales1@bolin.com or call +86-29-84355551 for consultation.

11.      Is it suitable for pharmaceutical applications?

o  Yes, for topical wound care and dermal support products.

12.      What certifications does the extract have?

o  ISO 9001, GMP, Halal, Kosher, and regulatory compliance certificates.

13.      What types of cosmetic products commonly use this extract?

o  Serums, creams, masks, lotions, and sun care products.

14.      What makes Shaanxi Bolin Biotechnology a reliable supplier?

o  Two decades of extraction experience, strict quality control, and international compliance.

Shaanxi Bolin Biotechnology Co., Ltd. Phone: +86-29-84355551 Email: sales1@bolin.com

Your trusted partner for high-quality botanical extracts and customized ingredient solutions. Contact us for formulation consultation and sample requests.